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Desmoplastic fibroma of the temporal bone
M L Pensak1, B R Nestok, H Van Loveren
1Department of Otolaryngology, University of Cincinnati College of Medicine, OH 45267-0528, USA.
Background:
Desmoplastic fibroma is a benign, locally aggressive, intraosseous neoplasm with a propensity for local recurrence. Desmoplastic fibroma most commonly originates within the mandible (70% of cases), and long bones with rare lesions reported in the maxillary, frontal, and parietal bones. We report two patients with desmoplastic fibroma arising within the temporal bone.
Study Design:
Case report and literature review.
Patients:
Two patients with desmoplastic fibroma with intracranial and extra cranial growth patterns are presented. Both were young females with aural fullness and decreased hearing.
Interventions:
Diagnostic and therapeutic.
Results:
Both tumors were surgically extirpated and the patients have remained disease free for 18-48 months. Neither tumor expressed estrogen or progesterone receptors.
Conclusion:
Desmoplastic fibroma is a highly invasive local destructive lesion which is best treated by nondestructive surgical intervention. Immunohistochemical analysis may demonstrate hormonal receptors, in which case Tamoxifen may reduce recurrence.
