Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apparent normal phenotype of Fgf6-/- mice

F Fiore1, J Planche, P Gibier

  • 1Laboratoire d'Oncologie Moléculaire, U119 INSERM, Marseille, France.

The International Journal of Developmental Biology
|August 1, 1997
PubMed
Summary

Fibroblast growth factor 6 (FGF6) is primarily expressed in skeletal muscle. FGF6 gene disruption in mice did not affect viability or fertility, suggesting it is not essential for basic life functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators.

Leukemia·2006
Same author

Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.

Oncogene·2006
Same author

Myeloproliferative disorders: premalignant, stem cell, G1 diseases?

Leukemia·2006
Same author

t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera.

Leukemia·2006
Same author

A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma.

Leukemia·2006
Same author

[DNA microarrays for gene expression profiling of breast cancer: principles and prognostic applications].

Pathologie-biologie·2005

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Fibroblast growth factors (FGFs) are crucial signaling molecules involved in various biological processes.
  • FGF6, the sixth member of the FGF family, exhibits restricted expression in skeletal muscle.
  • The specific role of FGF6 in mammalian physiology remains largely uncharacterized.

Purpose of the Study:

  • To elucidate the in vivo function of FGF6.
  • To investigate the necessity of FGF6 for skeletal muscle development and maintenance.
  • To determine the physiological impact of FGF6 absence in a model organism.

Main Methods:

  • Generation of mouse mutants with a homozygous disruption of the Fgf6 gene.
  • Phenotypic analysis of Fgf6 knockout mice, including assessment of viability, fertility, and general health.

Related Experiment Videos

  • Histological examination of skeletal muscle tissue (if applicable, though not explicitly stated in the abstract).

    • Main Results:

    • Mice with a complete knockout of the Fgf6 gene were successfully generated.
    • These Fgf6-deficient mice were viable and fertile.
    • No apparent abnormalities or essential function deficits were observed in the Fgf6 knockout animals.

    Conclusions:

    • FGF6 is not essential for the viability or reproductive capacity of laboratory mice.
    • The absence of FGF6 does not lead to overt phenotypic defects under standard laboratory conditions.
    • Further studies may be needed to uncover potential subtle roles or context-specific functions of FGF6 in skeletal muscle.