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Penicillin-binding proteins and induction of AmpC beta-lactamase
C C Sanders1, P A Bradford, A F Ehrhardt
1Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
Antimicrobial Agents and Chemotherapy
|September 26, 1997
Abstract:
In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.