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Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages
1Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.
Antimicrobial Agents and Chemotherapy
|September 26, 1997
Abstract:
The combination of clarithromycin and pyrazinamide was found to be synergistic against Mycobacterium tuberculosis in human macrophages. MICs were four- to eightfold lower for this combination than they were for either drug alone. Clarithromycin and rifampin, however, had only an additive effect.