Related Experiment Videos
[Infection and sepsis in resuscitation]
P Rodrigo-Casanova1, J M García-Peña
1Servicio de Anestesiología y Reanimación, Hospital de Basurto, Bilbao.
Revista Espanola De Anestesiologia Y Reanimacion
|June 1, 1997
Summary
Recent advances in understanding infections and sepsis have yielded new antibiotics and insights into pathophysiology. However, clinical trials for immunologic therapies have not yet confirmed expected reductions in sepsis morbidity and mortality.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Immunology
Context:
- The field of infection and sepsis has seen rapid advancements in the last decade.
- New broad-spectrum antibiotics and insights into sepsis mechanisms have emerged.
- Understanding of cardiovascular dysfunction, cytokines, and the L-arginine-nitric oxide pathway in sepsis has grown.
Purpose:
- To review current concepts and definitions in infection and sepsis.
- To explore the pathophysiology of sepsis.
- To discuss prophylaxis and therapeutic strategies for infection and sepsis.
Summary:
- Significant progress in understanding infections and sepsis, including new antibiotics and detailed pathophysiology.
- Despite advances, immunologic therapies have not yet met expectations in reducing sepsis-related mortality in clinical trials.
- This review covers definitions, pathophysiology, prophylaxis, and treatment of infection and sepsis.
Impact:
- Highlights the gap between research discoveries and clinical confirmation of reduced sepsis mortality.
- Provides a comprehensive overview of current knowledge and therapeutic approaches for clinicians.
- Aims to guide future research and clinical practice in managing sepsis effectively.