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Nitric oxide

R A Robbins1, M B Grisham

  • 1Research Service, Overton Brooks VA Medical Center, Shreveport, LA 71101, USA.

The International Journal of Biochemistry & Cell Biology
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Nitric oxide (NO), a gas produced from arginine, has diverse biological roles including immune responses and smooth muscle relaxation. Its levels are being explored for therapeutic uses and diagnosing respiratory conditions like asthma.

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Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • Nitric oxide (NO) is a critical signaling molecule produced from arginine by NO synthases.
  • NO participates in diverse physiological processes, including smooth muscle relaxation, neurotransmission, and immune modulation.
  • Dysregulation of NO pathways is implicated in various pathophysiologic conditions.

Purpose of the Study:

  • To review the multifaceted biological activities of nitric oxide.
  • To discuss the therapeutic potential and diagnostic applications of nitric oxide modulation.
  • To highlight ongoing research in nitric oxide-based therapies and diagnostics.

Main Methods:

  • Literature review of nitric oxide's biological roles and clinical applications.
  • Analysis of current therapeutic strategies involving nitric oxide administration or inhibition.

Related Experiment Videos

  • Evaluation of diagnostic methods utilizing exhaled nitric oxide measurements.

    • Main Results:

    • Nitric oxide interacts with superoxide to form peroxynitrite, mediating bactericidal and cytotoxic effects.
    • Nitric oxide plays a key role in smooth muscle relaxation, neurotransmission, and inflammation modulation.
    • Therapeutic strategies include inhaled NO for respiratory distress and NO synthase inhibitors for sepsis.
    • Exhaled NO levels show promise for assessing airway inflammation in asthma.

    Conclusions:

    • Nitric oxide is a versatile molecule with significant implications in health and disease.
    • Modulation of nitric oxide pathways offers therapeutic opportunities for various conditions.
    • Monitoring exhaled nitric oxide is a valuable tool for diagnosing and managing respiratory inflammatory disorders.