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A fatality due to moclobemide

C Camaris1, D Little

  • 1Department of Anatomical Pathology, Westmead Hospital, Sydney, Australia.

Journal of Forensic Sciences
|September 26, 1997
PubMed
Summary
This summary is machine-generated.

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This case report details a rare fatality from moclobemide, a selective reversible MAO-A inhibitor. The death was attributed to moclobemide toxicity alone, not serotonin syndrome, highlighting potential risks.

Area of Science:

  • Pharmacology
  • Toxicology
  • Forensic Medicine

Background:

  • Moclobemide is a selective and reversible inhibitor of monoamine oxidase type A (MAO-A).
  • Previous literature suggests moclobemide has a good safety profile, even in overdose.
  • Reported fatalities have typically involved interactions with other serotonergic agents, leading to serotonin syndrome.

Observation:

  • A 48-year-old female with a history of depression and suicide attempts was found deceased.
  • Autopsy showed no significant natural disease or injury.
  • Toxicologic analysis detected moclobemide blood concentration of 137 mg/L and liver concentration of 432 mg/kg, with low levels of other psychotropic medications.

Findings:

  • The cause of death was determined to be acute poisoning by moclobemide.

Related Experiment Videos

  • This case represents the first reported fatality attributed solely to the toxic effects of moclobemide.

    • Implications:

    • This case challenges the perception of moclobemide's safety in overdose.
    • It underscores the importance of considering direct toxicity of moclobemide, even in the absence of drug interactions.
    • Further research into the toxicodynamics and therapeutic drug monitoring of moclobemide may be warranted.