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A single nucleotide is a sufficient 5' untranslated region for translation in an eukaryotic in vitro system
1Dept. of Biochemistry, McMaster University, Hamilton, ON, Canada.
FEBS Letters
|September 26, 1997
Abstract:
The 5' untranslated region of an RNA molecule is thought to play an important role in the regulation of translation. Following a recent report that a single nucleotide is sufficient to act in this role in the unicellular organism Giardia, we show that this is also the case for a mammalian in vitro system. These results also demonstrate that an RNA can initiate translation from a start codon where an ideal translational consensus sequence is impossible.