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Complete nucleotide sequence of the HLA-DRB1 *1302 allele
N Martinez-Quiles1, J M Martin-Villa, J Martinez-Laso
1Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain.
Abstract:
Sequencing studies of HLA class II molecules have focused almost exclusively on its exon 2. The complete cDNA sequence of the DRB*1302 allele is reported here for the first time. A conservative polymorphism was detected outside the exon 2 at residue 206; these changes can only be recorded if complete cDNA sequences are studied, and may be of value in drawing evolutive inferences.