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Plasmids in Lactobacillus

T T Wang1, B H Lee

  • 1Department of Food Science and Agricultural Chemistry, McGill University, Quebec, Canada.

Critical Reviews in Biotechnology
|January 1, 1997
PubMed
Summary
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Lactobacillus plasmids are common, with 38% of species harboring them. These plasmids, often replicating via a rolling-circle mechanism, have diverse applications in genetic engineering and bacterial identification.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Plasmids are extrachromosomal DNA elements frequently found in bacteria, including the genus Lactobacillus.
  • Understanding Lactobacillus plasmid distribution, structure, and function is crucial for genetic manipulation and biotechnological applications.

Purpose of the Study:

  • To review the current knowledge on Lactobacillus plasmids, covering their distribution, structure, replication mechanisms, and functional applications.
  • To highlight the potential of these plasmids in vector construction and for the identification, detection, and modification of Lactobacillus species.

Main Methods:

  • Literature review of studies on Lactobacillus plasmids.
  • Analysis of plasmid characteristics including size, copy number, and sequence homology.

Related Experiment Videos

  • Examination of plasmid replication mechanisms, particularly rolling-circle replication.
  • Assessment of plasmid host range and functional gene content.

    • Main Results:

    • Approximately 38% of Lactobacillus species harbor plasmids ranging from 1.2 to 150 kb.
    • Small Lactobacillus plasmids share similarities with single-strand plasmids from other Gram-positive bacteria and replicate via rolling-circle mechanism.
    • Some Lactobacillus plasmids exhibit broad host range, functioning in other Gram-positive bacteria and even Escherichia coli.
    • Plasmid-encoded functions have been identified and utilized for vector construction and Lactobacillus manipulation.

    Conclusions:

    • Lactobacillus plasmids are diverse and possess significant potential for biotechnological applications.
    • The rolling-circle replication mechanism is prevalent in small Lactobacillus plasmids.
    • Lactobacillus plasmids are valuable tools for genetic engineering, identification, and modification of these bacteria.