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Updated: Aug 9, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Interferon regulatory factor 1 is induced by interferon-gamma equally in neurons and glial cells
H E Thomas1, R Dutton, P F Bartlett
1Burnet Clinical Research Unit, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Parkville. Vic., Australia.
Abstract:
Class I MHC protein is induced in glia but not mature neurons by IFN-gamma. We have compared IFN-gamma signal transduction in these populations. There were identical levels of STAT1 homodimers and IRF-1 by gel-shift and IRF-1 mRNA was induced equally. However class I MHC, beta2-microglobulin and interleukin 1-beta converting enzyme mRNA levels were greatly reduced in neurons. These experiments show that there is no defect in expression of IRF-1 in response to IFN-gamma in mature mouse neurons but that insufficient class I MHC gene expression is induced for detectable cell surface protein expression.
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