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Recommendations from the National Multiple Sclerosis Society Clinical Outcomes Assessment Task Force

R Rudick1, J Antel, C Confavreux

  • 1Mellen Center, Cleveland Clinic Foundation, OH 44106, USA.

Annals of Neurology
|October 23, 1997
PubMed
Summary

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The National Multiple Sclerosis Society recommends quantitative functional composites for clinical trials. This new approach combines measures into a single score for improved precision and sensitivity in multiple sclerosis research.

Area of Science:

  • Neurology
  • Clinical Trials
  • Biostatistics

Background:

  • Recommendations for improved clinical outcomes assessment in multiple sclerosis (MS) trials.
  • Established by the National Multiple Sclerosis Society's Clinical Outcomes Assessment Task Force in 1994.
  • Based on 2.5 years of deliberation and data analysis.

Framework:

  • Proposed a new measurement approach using quantitative functional composites.
  • Combines simple quantitative measures from major MS clinical dimensions into a single score.
  • Utilizes general principles and desirable measurement attributes for assessment.

Implementation:

  • Assessed alternative measurement techniques and clinical scales.
  • Analyzed existing multiple sclerosis (MS) data sets.

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  • Delineates necessary studies for further refinement of the proposed approach.

    • Implications:

    • Quantitative functional composites offer improved precision and sensitivity for MS clinical trials.
    • Aims to enhance the effectiveness of future controlled clinical trials.
    • Provides a refined outcome measure for multiple sclerosis research.