Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brachytherapy in orbital tumors

J W Tyl1, L E Blank, L Koornneef

  • 1Orbital Center, Amsterdam, The Netherlands.

Ophthalmology
|October 6, 1997
PubMed
Summary

Iridium-192 brachytherapy offers excellent outcomes for orbital tumors, preserving eyes in most cases. While effective, advanced disease may still require external radiation or surgery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corneal astigmatism in Graves' ophthalmopathy.

Eye (London, England)·2005
Same author

The intranasal ostium after external dacryocystorhinostomy and the internal opening of the lacrimal canaliculi.

Orbit (Amsterdam, Netherlands)·2002
Same author

Local tract metastasis of prostatic adenocarcinoma 8 years after (125)iodine brachytherapy.

The Journal of urology·2001
Same author

Office hours pulsed brachytherapy boost in breast cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2001
Same author

Bony orbital development after early enucleation in humans.

The British journal of ophthalmology·2001
Same author

Brachytherapy with transperineal (125)Iodine seeds for localized prostate cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2000

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Oncology

Background:

  • Orbital tumors present a significant challenge in treatment planning.
  • External beam radiation therapy (EBRT) has been associated with notable complications.
  • Brachytherapy offers a localized radiation approach.

Purpose of the Study:

  • To assess if iridium-192 brachytherapy reduces complications compared to EBRT for orbital tumors.
  • To evaluate the efficacy and safety of brachytherapy in managing orbital malignancies.

Main Methods:

  • Retrospective clinical series review of 25 patients with orbital tumors.
  • Treatment administered between 1988 and 1995 using iridium-192 brachytherapy.
  • Average follow-up of 40 months (range, 16-88 months).

Main Results:

  • 24 out of 25 patients achieved no evidence of disease.
  • Eye preservation was successful in 22 patients; 3 required exenteration.
  • Post-therapy visual acuity averaged 20/40, with a range from no light perception to 20/20.

Conclusions:

  • Brachytherapy demonstrates excellent results as an alternative to exenteration for many orbital tumors.
  • Localized brachytherapy can achieve favorable outcomes and preserve ocular function.
  • External radiation therapy or surgery may still be necessary for advanced or recurrent orbital disease.

Related Experiment Videos