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Yellow nail syndrome

A Hershko1, B Hirshberg, M Nahir

  • 1Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel.

Postgraduate Medical Journal
|August 1, 1997
PubMed
Summary
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Yellow Nail Syndrome, a condition first identified in the 1960s, initially presents with nail changes but affects multiple organ systems. This review details its known associations with other diseases.

Area of Science:

  • Medicine
  • Dermatology
  • Internal Medicine

Background:

  • Yellow Nail Syndrome (YNS) was first described as a distinct clinical entity in the 1960s.
  • Initially recognized for its characteristic nail abnormalities, YNS is now understood to be a multisystem disorder.
  • The association of YNS with various other medical conditions is well-documented in scientific literature.

Purpose of the Study:

  • To provide a comprehensive review of the medical literature concerning Yellow Nail Syndrome.
  • To consolidate current knowledge on the clinical manifestations, pathophysiology, and associated diseases of YNS.

Main Methods:

  • A systematic review of existing medical literature was conducted.
  • Relevant studies and case reports on Yellow Nail Syndrome were identified and analyzed.

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Main Results:

  • Nail abnormalities, including yellowing, thickening, and slow growth, are the hallmark initial signs of YNS.
  • The syndrome is associated with respiratory conditions (e.g., pleural effusions, chronic bronchitis) and lymphedema.
  • Numerous other comorbidities have been reported in patients with YNS, highlighting its systemic nature.

Conclusions:

  • Yellow Nail Syndrome is a complex disorder with systemic implications beyond its initial nail findings.
  • Understanding the diverse manifestations and associations of YNS is crucial for accurate diagnosis and patient management.
  • Further research is warranted to elucidate the underlying mechanisms and optimize treatment strategies for YNS.