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Chronic radiation proctitis treated with hyperbaric oxygen

D C Warren1, P Feehan, J B Slade

  • 1Department of Hyperbaric Medicine, 60th Medical Group, Travis AFB, California 94535-1800, USA.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|October 6, 1997
PubMed
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Hyperbaric oxygen therapy (HBO2) effectively treats chronic radiation proctitis, a common complication of pelvic irradiation. This study found a 64% response rate, indicating HBO2 is a viable treatment option for radiation-induced proctitis.

Area of Science:

  • Gastroenterology
  • Oncology
  • Hyperbaric Medicine

Background:

  • Chronic proctitis is a frequent complication following therapeutic irradiation, particularly for pelvic cancers.
  • Radiation-induced proctitis can significantly impact patient quality of life.

Purpose of the Study:

  • To evaluate the efficacy of hyperbaric oxygen therapy (HBO2) in treating chronic radiation-induced proctitis.
  • To determine the response rate and long-term outcomes of HBO2 for this condition.

Main Methods:

  • A cohort of 14 patients with chronic radiation proctitis received HBO2 therapy between 1992 and 1995.
  • Patients were treated in monoplace chambers at either 2.0 atm or 2.36 atm abs.
  • Follow-up ranged from 5 to 35 months.

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Main Results:

  • A total response rate of 64% was observed, with 8 patients achieving complete symptom resolution and 1 experiencing substantial improvement.
  • Five patients (36%) were classified as non-responders, with some experiencing relapse after treatment.
  • Sigmoidoscopy confirmed documented improvement in responders, while non-responders showed no such changes.

Conclusions:

  • Hyperbaric oxygen therapy (HBO2) demonstrates significant efficacy in managing chronic radiation proctitis.
  • HBO2 should be considered a valuable therapeutic option for patients suffering from radiation-induced proctitis.