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Scleroderma and silicone breast implants

D Whorton¹, O Wong

¹Applied Health Sciences, San Mateo, California, USA.

The Western Journal of Medicine

|October 6, 1997

Summary

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Silicone breast implants are not linked to scleroderma. Extensive research, including case-control and prospective studies, found no evidence supporting a causal relationship between breast implants and this connective tissue disease.

Area of Science:

Rheumatology
Plastic Surgery
Epidemiology

Background:

Scleroderma is a rare systemic connective tissue disease.
Case reports in the 1980s suggested a link between silicone breast implants and scleroderma.
By 1993, 38 of 72 reported cases of connective tissue disease in women with breast implants were scleroderma.

Purpose of the Study:

To investigate the potential association between silicone breast implants and the development of scleroderma.
To qualitatively review epidemiologic studies and quantitatively summarize case-control studies.

Main Methods:

Conducted a qualitative review of published epidemiologic studies.
Performed a quantitative meta-analysis of five case-control studies.
Included data from four prospective studies and eight other epidemiologic studies.

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Main Results:

Epidemiologic studies, including case-control and prospective designs, were reviewed.
Meta-analysis of case-control studies did not reveal a significant association.
Eight other studies identified no cases of scleroderma in women with breast implants.

Conclusions:

Current epidemiologic data do not support a hypothesis linking silicone breast implants to scleroderma.
The available evidence does not indicate a causal relationship between breast implants and scleroderma.
Further research may be warranted, but existing data are inconclusive.