Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toe amputation in the diabetic patient

M D Kerstein1, V Welter, V Gahtan

  • 1Department of Surgery, Medical College of Pennsylvania, Philadelphia, USA.

Surgery
|October 6, 1997
PubMed
Summary

For diabetic patients with osteomyelitis and good circulation, prompt toe amputation may be more practical than prolonged antibiotic treatment. This approach can potentially reduce functional days lost and treatment costs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardioprotective actions of transforming growth factor-β.

Trends in cardiovascular medicine·2011
Same author

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse.

Biology of reproduction·2008
Same author

Smad3 deficiency inhibits v-ras-induced transformation by suppression of JNK MAPK signaling and increased farnesyl transferase inhibition.

Oncogene·2007
Same author

Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion.

Developmental biology·2002
Same author

Meeting report: signaling schemes for TGF-beta.

Science's STKE : signal transduction knowledge environment·2001
Same author

Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis.

Advances in cancer research·2001

Area of Science:

  • Podiatric surgery
  • Diabetic foot complications
  • Infectious diseases

Background:

  • Osteomyelitis in diabetic patients presents a treatment challenge, balancing surgical intervention with prolonged antibiotic therapy.
  • Assessing the practicality of toe amputation versus conservative antibiotic treatment is crucial for diabetic patients with osteomyelitis and adequate circulation.

Purpose of the Study:

  • To evaluate the clinical and economic benefits of prompt toe amputation in diabetic patients with osteomyelitis and good circulation.

Main Methods:

  • Retrospective study of 141 diabetic patients with osteomyelitis who underwent toe-ray amputation.
  • Analysis of ankle/brachial index to confirm good circulation.
  • Evaluation of functional days lost and treatment costs associated with antibiotic therapy.

Main Results:

  • The mean ankle/brachial index was 0.81, indicating good circulation in the study cohort.
  • Patients experienced a mean of 39 functional days lost due to antibiotic therapy.
  • The estimated cost for 6-8 weeks of preoperative antibiotic therapy ranged from $900 to $2240, with a mean of $1440.

Conclusions:

  • Prompt toe amputation can be a beneficial treatment option for diabetic patients presenting with osteomyelitis and good peripheral circulation.
  • This approach may lead to fewer functional days lost compared to prolonged antibiotic treatment.
  • Early surgical intervention could offer a more practical and potentially cost-effective solution.

Related Experiment Videos