Related Experiment Videos
[Study on the change in serum enzyme activity during acute aortic dissection]
Rinsho Kyobu Geka = Japanese Annals of Thoracic Surgery
|December 1, 1989
Summary
In uncomplicated aortic dissection, elevated serum creatine kinase (CK) activity is transient. This elevation is linked to CK release from the dissected aortic wall into the bloodstream.
Area of Science:
- Cardiovascular Surgery
- Biochemistry
Background:
- Acute aortic dissection is a life-threatening condition.
- Complications significantly impact patient outcomes and clinical presentation.
Purpose of the Study:
- To investigate the correlation between serum enzyme activity and complications in acute aortic dissection.
- To determine the source of elevated creatine kinase (CK) in uncomplicated cases.
Main Methods:
- Patients with acute aortic dissection were categorized into 'complication-free' and 'complication' groups.
- Serum enzyme levels (CK, LDH, GOT, GPT) were monitored and compared between groups.
- Creatine kinase (CK) activity was also measured in aortic wall tissue samples from autopsy.
Main Results:
- The complication-free group showed a significant, transient elevation in serum CK, peaking on day one and normalizing by day four.
- In the complication group, serum enzyme fluctuations correlated with specific complications and clinical course.
- Aortic wall specimens exhibited high CK activity (585.0 +/- 35.3 IU/g protein).
Conclusions:
- Transient elevation of serum CK in uncomplicated aortic dissection is likely due to CK release from the dissected aortic wall.
- Serum enzyme profiles may offer insights into the presence and type of complications in aortic dissection.