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[APC, beta-catenin, DLG]
1Dept. of Oncogene Research, Osaka University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 6, 1997
Abstract:
The APC gene is mutated in the majority of colorectal tumors. The product of this gene is a 300 kDa protein associated with beta-catenin and the human homolog of the Drosophila tumor suppressor DLG. The study of the function of APC provides important insights into the mechanisms of the development of colorectal tumor.