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Evolution of cell lineage

P W Sternberg1, M A Félix

  • 1Howard Hughes Medical Institute, California Institute of Technology Biology, Pasadena 91125, USA. pws@cco.caltech.edu

Current Opinion in Genetics & Development
|August 1, 1997
PubMed
Summary
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Studies on nematodes and mollusks reveal how fixed cell lineages offer insights into genetic programming and evolutionary flexibility. Comparative developmental biology illuminates the evolution of cell fate determination and asymmetry.

Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Genetics

Background:

  • Fixed cell lineages in organisms like nematodes and mollusks provide models for studying developmental precision.
  • Understanding cell fate determination is crucial for comprehending evolutionary processes.

Purpose of the Study:

  • To investigate the genetic programming underlying developmental precision in fixed cell lineages.
  • To explore the evolution of flexibility in developmental processes.
  • To examine the evolution of asymmetry through comparative developmental studies.

Main Methods:

  • Comparative analysis of developmental pathways in nematodes and mollusks.
  • Genetic studies focusing on cell lineage determination.
  • Evolutionary modeling of cell fate specification.

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Main Results:

  • Fixed cell lineages demonstrate the genetic control of developmental precision.
  • Evidence suggests evolution from stochastic cell fate to fixed lineages and from cell interaction to autonomous specification.
  • Comparative studies highlight the evolutionary pathways leading to developmental asymmetry.

Conclusions:

  • Fixed cell lineages are key to understanding the genetic basis of precise development and its evolutionary adaptability.
  • Developmental processes evolve towards greater precision and autonomy.
  • Asymmetry in development has a significant evolutionary history that can be studied comparatively.