Related Experiment Video
Updated: Sep 30, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
Involvement of the dorsal paratrigeminal nucleus in visceral pain-related phenomena
K Bon1, M Lantéri-Minet, D Menétrey
1Unit 161, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Abstract:
Cyclophosphamide is an antitumor agent that generates evolving cystitis through the release of toxic urinary by-products, mostly acrolein, that attack the bladder walls. Using c-fos expression, which permits quantitative analysis of neural activity, we demonstrated that the paratrigeminal nucleus is involved in processing the inputs that this disease generates. c-Fos staining in the paratrigeminal nucleus increases regularly reaching a plateau over the 4 h postinjection period during which the disease develops. The degree of staining is directly correlated with that of the subnucleus medialis of the nucleus of the solitary tract, which is one of the main structures that processes cystitis-related inputs at the supraspinal level.
Related Concept Videos
Thermosensation
Nociception
Diencephalon: Hypothalamus and Coordination
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Major Somatic Sensory Pathways
Pathophysiology of Vomiting
Pain

