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Related Experiment Videos

Controlled ovarian hyperstimulation: comparison between u-hFSH conventional protocol and a personalized approach

M Pellicano1, F Zullo, C Di Carlo

  • 1Department of Gynecology and Obstetrics, University of Naples Federico II, Italy.

International Journal of Fertility and Women'S Medicine
|July 1, 1997
PubMed
Summary

A personalized controlled ovarian hyperstimulation (COH) protocol using body mass index (BMI) and waist/hip ratio (WHR) improved pregnancy rates in infertile couples. This tailored approach resulted in more single and twin pregnancies without increasing risks of multiple pregnancies or OHSS.

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Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatment
  • Clinical Gynecology

Background:

  • Anovulatory infertility, mild endometriosis-related infertility, and unexplained infertility affect numerous couples.
  • Conventional controlled ovarian hyperstimulation (COH) protocols may not optimize outcomes for all infertile patients.
  • Personalized medicine approaches are increasingly recognized for improving therapeutic effectiveness.

Purpose of the Study:

  • To compare the effectiveness of a personalized COH protocol (Group A) with a conventional protocol (Group B).
  • The personalized protocol was based on body mass index (BMI) and waist/hip ratio (WHR).
  • To evaluate pregnancy rates and cycle characteristics in infertile couples undergoing COH.

Main Methods:

  • A comparative study involving two groups of infertile couples undergoing COH.

Related Experiment Videos

  • Group A utilized a personalized COH protocol based on BMI and WHR.
  • Group B received a conventional COH protocol.

    • Main Results:

    • Group A demonstrated a significantly higher pregnancy rate and increased number of multifollicular cycles compared to Group B.
    • Pregnancy and ovulatory cycle rates were higher, though not statistically significant, in Group A.
    • Group B showed a non-significant increase in monofollicular cycles and stimulation duration.

    Conclusions:

    • A personalized COH protocol using BMI and WHR enhances therapeutic effectiveness in infertile couples.
    • This tailored approach leads to a greater incidence of single and twin pregnancies.
    • The personalized protocol achieved these outcomes without a significant rise in high-order multiple pregnancies or severe ovarian hyperstimulation syndrome (OHSS).