Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyurethane elastomer biostability

K Stokes1, R McVenes, J M Anderson

  • 1Medtronic, Inc., Minneapolis, MN 55432-3576, USA.

Journal of Biomaterials Applications
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in lipoprotein(a) levels measured by six kit methods during growth hormone treatment of growth hormone-deficient adults.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2001
Same author

Shear stress-induced apoptosis of adherent neutrophils: a mechanism for persistence of cardiovascular device infections.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

High molecular weight kininogen inhibition of endothelial cell function on biomaterials.

Journal of biomedical materials research·2000
Same author

Monocyte adhesion to platelet concentrate storage bags and cytokine production.

Vox sanguinis·2000
Same author

Early diagnosis of right ventricular or posterior infarction associated with inferior wall left ventricular acute myocardial infarction.

The American journal of cardiology·2000
Same author

CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin.

The Journal of biological chemistry·2000
Same journal

Effect of alloying and adding hydroxyapatite on the mechanical and corrosive properties of porous magnesium (Mg).

Journal of biomaterials applications·2026
Same journal

From leaf to cellulose scaffold: Decellularization and multi-scale characterization of <i>Neolamarckia cadamba</i> leaf for biomedical applications.

Journal of biomaterials applications·2026
Same journal

Gelatin-based cryogels seeded with exosomes enhance osteogenic activity and bone regeneration in a rabbit femoral defect model.

Journal of biomaterials applications·2026
Same journal

Carbon monoxide-releasing molecule-3 eradicates mature <i>Enterococcus faecalis</i> biofilms and inhibits recolonization.

Journal of biomaterials applications·2026
Same journal

Natural melanin nanoparticles modified with glycol chitosan for enhanced delivery of oxaliplatin.

Journal of biomaterials applications·2026
Same journal

Epidural thickness of the dura sealants HEMOPATCH® and TACHOSIL® after elective supratentorial craniotomy: A comparative retrospective monocentric cohort study.

Journal of biomaterials applications·2026
See all related articles

A new polycarbonate polyurethane shows improved biostability for implantable devices, outperforming traditional polyether polyurethanes by resisting degradation like hydrolysis, environmental stress cracking, and metal ion oxidation.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Engineering

Background:

  • Polyurethanes are widely used in implantable medical devices due to their favorable mechanical and biological properties.
  • Traditional polyurethanes, including polyester and polyether types, face challenges with in vivo degradation.
  • Polyester polyurethanes degrade via hydrolysis, limiting their use in long-term applications, while polyether polyurethanes are susceptible to oxidative degradation (environmental stress cracking, metal ion oxidation) and mineralization.

Purpose of the Study:

  • To evaluate the in vivo biostability of a novel polycarbonate polyurethane.
  • To compare the degradation resistance of the new polycarbonate polyurethane against established polyether polyurethanes.

Main Methods:

  • Early in vivo qualification tests were conducted.

Related Experiment Videos

  • Assessment of degradation mechanisms including hydrolysis, environmental stress cracking (ESC), and metal ion oxidation (MIO) was performed.

    • Main Results:

    • The new polycarbonate polyurethane demonstrated superior biostability compared to polyether polyurethanes.
    • No evidence of hydrolysis, ESC, or MIO was observed in the polycarbonate polyurethane during the tests.

    Conclusions:

    • Polycarbonate polyurethanes represent a promising advancement in biomaterial development for implantable devices.
    • Their enhanced resistance to in vivo degradation suggests potential for improved longevity and performance in medical implants.