Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implication of mitochondria in apoptosis

P X Petit1, N Zamzami, J L Vayssière

  • 1Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, UPR 9061, Gif-sur-Yvette, France.

Molecular and Cellular Biochemistry
|October 6, 1997
PubMed
Summary

Programmed cell death (PCD) involves diverse signaling pathways. Mitochondria play a key role in the effector phase, preceding nuclear changes, indicating their critical involvement in apoptosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.

Cell death and differentiation·2026
Same author

Impaired autophagy increases susceptibility to endotoxin-induced chronic pancreatitis.

Cell death & disease·2020
Same author

The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor?

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

T-cell bispecific antibodies in node-positive breast cancer: novel therapeutic avenue for MHC class I loss variants.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

MDM2-TP53 Crossregulation: An Underestimated Target to Promote Loss of TP53 Function and Cell Survival.

Trends in cancer·2018
Same author

Predictors of responses to immune checkpoint blockade in advanced melanoma.

Nature communications·2017

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Programmed cell death (PCD), or apoptosis, features a complex induction phase with varied signaling pathways.
  • The effector phase involves convergence into fewer pathways, leading to irreversible cell commitment to death.

Purpose of the Study:

  • To investigate the role of cytoplasmic structures, particularly mitochondria, in the effector phase of apoptosis.
  • To explore the relationship between mitochondrial alterations and the late degradation phase of apoptosis.

Main Methods:

  • Review and synthesis of accumulating evidence on mitochondrial involvement in apoptosis.
  • Discussion of the link between mitochondrial function, permeability transition pore, and PCD.

Main Results:

Related Experiment Videos

  • Mitochondrial function and structure alterations precede nuclear features of apoptosis.
  • Cytoplasmic structures, including mitochondria, are critical participants in the effector stage of PCD.

Conclusions:

  • Mitochondrial alterations are crucial early events in the apoptotic process.
  • These findings highlight the significance of mitochondria in committing cells to death, prior to late-stage nuclear events.