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Acute renal failure associated with minimal change nephrotic syndrome in an elderly adult
A Morita1, E Ishimura, T Tabata
1Inoue Hospital, Osaka, Japan.
Abstract:
We report a 66-year-old man with minimal change nephrotic syndrome (MCNS) that was associated with reversible acute renal failure (ARF) caused by acute tubular necrosis (ATN). He had a subacute onset of proteinuria and progressive azotemia. Hemodialysis (HD) was required to improved azotemia. Renal biopsy revealed minor glomerular abnormalities associated with ATN. While continuing HD, steroid therapy was started, which subsequently allowed the patient to be weaned from HD and relieved from NS. In this patient, histological examination and clinical course suggested that ATN was probably induced by hypovolemia due to MCNS.
Insights
Minimal change nephrotic syndrome can cause acute kidney injury due to acute tubular necrosis. Steroid therapy effectively treated both conditions, allowing recovery from acute renal failure and nephrotic syndrome.
Area of Science:
- Nephrology
- Pathology
Background:
- Minimal change nephrotic syndrome (MCNS) is a common cause of nephrotic syndrome in adults.
- Acute renal failure (ARF) can be a complication of MCNS, though less common.