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Related Experiment Videos

Linking protein kinase C to cell-cycle control

E Livneh1, D D Fishman

  • 1Department of Immunology and Microbiology, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel. etta@bgumail.bgu.ac.il

European Journal of Biochemistry
|August 15, 1997
PubMed
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Protein Kinase C (PKC) regulates cell cycle progression, inhibiting G1 phase and impacting G2/M transition. This conserved mechanism links signal transduction to cell cycle machinery in yeast and mammals.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein Kinase C (PKC) isoenzymes are crucial for various cellular processes, including growth, differentiation, and cell death.
  • Emerging evidence suggests a significant role for PKC in regulating the cell cycle.
  • A study in yeast highlights a functional link between PKC and cell cycle control, indicating conserved pathways.

Purpose of the Study:

  • To review current data on cell cycle components targeted by PKC regulation.
  • To explore the mechanisms by which PKC influences cell cycle progression.
  • To understand PKC's conserved role in linking signal transduction and cell cycle machinery.

Main Methods:

  • Literature review of published data on PKC and cell cycle regulation.

Related Experiment Videos

  • Analysis of studies investigating PKC's effects on specific cell cycle proteins and phases.
  • Examination of evidence from both yeast and mammalian systems.

    • Main Results:

    • PKC regulates the cell cycle at two key points: G1 progression and G2/M transition.
    • PKC activation inhibits cell cycle progression in mid to late G1 by blocking retinoblastoma protein (Rb) phosphorylation.
    • PKC activation reduces cyclin-dependent kinase 2 (Cdk2) activity through various mechanisms, including altered kinase activity, cyclin expression, and expression of Cdk inhibitors (p21WAF1, p27KIP1).
    • PKC also influences G2/M transition, with strong evidence implicating it in lamin B phosphorylation and nuclear envelope disassembly.

    Conclusions:

    • PKC acts as a conserved regulator of cell cycle events, bridging signal transduction pathways and the cell cycle machinery.
    • PKC plays a critical role in controlling cell cycle progression at both G1 and G2/M phases.
    • Further research into PKC's cell cycle functions can elucidate fundamental mechanisms of cell growth and division.