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Published on: February 15, 2018
Exclusive breastfeeding protects against bacterial colonization and day care exposure to otitis media
L C Duffy1, H Faden, R Wasielewski
1Department of Pediatrics, Children's Hospital, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14209, USA.
Insights
Exclusive breastfeeding significantly reduces the risk of acute otitis media (AOM) and otitis media with effusion (OME) in infants. Not being breastfed, early pathogen colonization, and day care increase the likelihood of these ear infections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Acute otitis media (AOM) and otitis media with effusion (OME) are common childhood infections.
- Breastfeeding and environmental factors are suspected to influence the incidence of these conditions.
Purpose of the Study:
- To assess the relationship between exclusive breastfeeding and other environmental exposures with AOM and OME in infants.
- To identify modifiable risk factors for middle ear infections in early childhood.
Main Methods:
- Prospective cohort study of 306 infants followed from birth.
- Data collected on breastfeeding exclusivity, parental smoking, day care, and family history.
- Tympanometry, otoscopy, and nasopharyngeal cultures used for diagnosis and pathogen detection.
Main Results:
- Exclusive breastfeeding for 6 months reduced the risk of AOM/OME by twofold compared to formula-feeding.
- Formula-feeding was the strongest predictor of middle ear infections.
- Early colonization with middle ear pathogens and day care were significant competing risk factors.
Conclusions:
- Not being breastfed, early age at pathogen colonization (<=3 months), and day care outside the home are modifiable risk factors for AOM and OME.
- Breastfeeding, even for short durations, reduces the onset of infant ear infections.
Objective:
We followed a cohort (N = 306) of infants at well-baby visits in two suburban pediatric practices to assess the relation of exclusive breastfeeding, and other environmental exposures, to episodes of acute otitis media (AOM) and otitis media with effusion (OME).
Methods:
Detailed prospective information about the exclusiveness of breastfeeding, parental smoking, day care attendance, and family history was obtained at scheduled clinic visits. Tympanometric and otoscopic examinations were used in the diagnosis of otitis media (OM). Nasopharyngeal cultures were performed at 1-6 months, and at 8, 10, 12, 15, 18, and 24 months of age to detect colonization with middle-ear pathogens.
Results:
Between 6 and 12 months of age, cumulative incidence of first OM episodes increased from 25% to 51% in infants exclusively breastfed and from 54% to 76% in infants formula-fed from birth. Peak incidence of AOM and OME episodes was inversely related to rates of breastfeeding beyond 3 months of age. A twofold elevated risk of first episodes of AOM or OME was observed in exclusively formula-fed infants compared with infants exclusively breast-fed for 6 months. In the logistic regression analysis, formula-feeding was the most significant predictor of AOM and OME episodes, although age at colonization with middle-ear pathogens and day care (outside the home) were significant competing risk factors. A hazard health model suggested additionally that breastfeeding, even for short durations (3 months), reduced onset of OM episodes in infancy.
Conclusions:
Modifiable factors in the onset of AOM and OME episodes during the first 2 years of life include early age at colonization (=3 months of age), day care outside the home, and not being breastfed.
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