Related Experiment Video
Updated: Aug 9, 2026

07:41
An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
Published on: November 13, 2016
Calcaneal osteomyelitis caused by nail puncture wounds
R T Laughlin1, F Reeve, D G Wright
1Wright State University, Department of Orthopedic Surgery, Dayton, Ohio 45440, USA.
Foot & Ankle International
|October 6, 1997
Summary
Nail puncture wounds can lead to calcaneus osteomyelitis. Diabetic patients with neuropathy face higher risks of multiple infections and amputation following such foot injuries.
Area of Science:
- Orthopedics
- Infectious Diseases
- Podiatry
Background:
- Plantar puncture wounds are common foot injuries.
- A small percentage (1.8%) of these wounds develop into osteomyelitis.
- Osteomyelitis of the calcaneus can result from puncture wounds, particularly those caused by nails.
Observation:
- This study reports on six patients who developed calcaneal osteomyelitis after a nail puncture wound to the heel.
- Patient characteristics, causative organisms, and outcomes were analyzed.
- Four patients were healthy, while two had diabetes mellitus.
Findings:
- Healthy patients typically had a single pathogenic organism cultured.
- Patients with systemic illness (diabetes mellitus) showed multiple pathogenic organisms.
- The only amputation occurred in a diabetic patient, indicating a poorer prognosis.
Implications:
- Diabetic patients with calcaneal osteomyelitis from nail punctures are prone to polymicrobial infections.
- The presence of diabetic neuropathy exacerbates the risk, potentially leading to chronic ulceration and increased amputation rates.
- Early recognition and management are crucial for preventing severe outcomes in diabetic individuals with puncture wound-related osteomyelitis.
Related Concept Videos
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

