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Recurrent lymphocytic hypophysitis: case report

H Nishioka¹, H Ito, C Fukushima

¹Department of Neurosurgery, Tokyo Medical College, Japan.

|October 6, 1997

Summary

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Recurrent lymphocytic hypophysitis, a rare pituitary inflammation, can occur years after initial diagnosis. Prompt corticosteroid treatment effectively resolves symptoms and reduces lesion size.

Area of Science:

Endocrinology
Neuro-oncology
Immunology

Background:

Lymphocytic hypophysitis (LYH) is an inflammatory pituitary disorder of increasing recognition.
Long-term outcomes and recurrence patterns of LYH remain incompletely understood.

Observation:

A 53-year-old woman with central diabetes insipidus was diagnosed with LYH via biopsy.
Following initial lesion regression, she developed recurrent symptoms including visual defects (bitemporal hemianopsia) due to a larger sellar lesion.
Adenohypophyseal function remained normal despite recurrent disease.

Findings:

Corticosteroid therapy rapidly resolved visual deficits and significantly reduced the recurrent sellar lesion.
This case represents the first reported instance of LYH recurrence after a long interval.

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Implications:

Long-term endocrinological and radiological monitoring is crucial for LYH patients.
Prompt steroid treatment is effective for histologically confirmed recurrent LYH.
This case expands the known clinical spectrum of LYH.