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[Clinical use of midazolam]
T Nishiyama1, C Furuya, K Hanaoka
1Department of Anesthesiology, Faculty of Medicine, University of Tokyo.
Masui. the Japanese Journal of Anesthesiology
|October 6, 1997
Summary
Midazolam is a versatile anesthetic agent used for premedication, induction, and maintenance of general anesthesia. It provides sedation and anti-anxiety effects, with careful dosing adjustments for specific patient populations.
Area of Science:
- Anesthesiology
- Pharmacology
Context:
- Midazolam is a commonly utilized medication in clinical anesthesia.
- Understanding its characteristics and applications is crucial for effective patient management.
Purpose:
- To elucidate the diverse applications of midazolam in various anesthetic settings.
- To provide guidance on optimal dosing and administration strategies for midazolam.
Summary:
- Midazolam serves as an effective premedication (0.04-0.08 mg.kg-1 IM), induction agent (synergistically with barbiturates/propofol), and maintenance agent in total intravenous anesthesia.
- It offers anti-anxiolytic and sedative effects during regional anesthesia (0.05 mg.kg-1 IV) and can prevent early awakening during cardiopulmonary bypass with minimal cardiodepressant effects.
- Dosage adjustments are necessary for elderly patients or those with hepatic or renal impairment due to increased midazolam effects.
Impact:
- Optimized use of midazolam can enhance patient comfort and safety during surgical procedures.
- This review aids anesthesiologists in tailoring midazolam therapy for improved anesthetic outcomes.
- Highlights the importance of individualized dosing in diverse patient groups.