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[Influence of fluid replacement on serum magnesium concentration and proper magnesium supplementation during general

R Sasaki1, K Hirota, K Nakamaru

  • 1Department of Anesthesiology, Toyama Medical and Pharmaceutical University School of Medicine.

Masui. the Japanese Journal of Anesthesiology
|October 6, 1997
PubMed

Insights

Fluid replacement during anesthesia can lower serum magnesium (Mg2+) levels. Supplementing magnesium (Mg2+) during surgery prevents these drops, especially with significant fluid infusion.

Area of Science:

  • Anesthesiology
  • Clinical Chemistry
  • Surgical Care

Background:

  • Fluid replacement therapy is common during general anesthesia.
  • Serum magnesium (Mg2+) levels can be affected by fluid administration.
  • Understanding Mg2+ balance is crucial for patient safety during surgery.

Purpose of the Study:

  • To investigate the impact of fluid replacement on serum magnesium (Mg2+) concentrations.
  • To determine optimal magnesium (Mg2+) supplementation strategies during general anesthesia.

Main Methods:

  • Thirty-eight patients undergoing elective surgery were randomized into five groups.
  • Groups received varying concentrations of magnesium (Mg2+) in Ringer solution, including a Mg2+-free control.
  • Serum and urine Mg2+ concentrations were measured during anesthesia.

Main Results:

  • Serum Mg2+ concentrations decreased in the Mg2+-free group, correlating with water balance.
  • This decrease is attributed to dilution from fluid replacement, as urinary Mg2+ was negligible.
  • Magnesium (Mg2+) supplementation in other groups inhibited the decline in serum Mg2+.
  • Serum Mg2+ remained stable in the group receiving 2.0 mmol.l-1 Mg2+.

Conclusions:

  • Magnesium (Mg2+) supplementation is necessary during general anesthesia when large volumes of fluid are infused.
  • Maintaining adequate serum Mg2+ levels is important for surgical patients receiving fluid therapy.
  • Specific Mg2+ concentrations may be required to counteract dilution effects.

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