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Synthesis, cytotoxicity and SAR of simple geiparvarin analogues
P Valenti1, A Rampa, M Recanatini
1Department of Pharmaceutical Sciences, University of Bologna, Italy.
Anti-Cancer Drug Design
|October 6, 1997
Abstract:
Some simple geiparvarin analogues, in which the coumarin moiety has been replaced with an X-substituted benzene ring, are described. The compounds were tested on LoVo cells (human colon carcinoma cell line) and some of them show a cytotoxicity comparable with that of the prototype. A QSAR analysis was also attempted, but it did not provide satisfactory results, mainly because of the limited range of variation of the biological activity.