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Related Experiment Videos

Transgenic dairy cattle: genetic engineering on a large scale

R J Wall1, D E Kerr, K R Bondioli

  • 1Gene Evaluation and Mapping Laboratory, USDA-ARS-Livestock and Poultry Science Institute, Beltsville, MD 20705, USA.

Journal of Dairy Science
|October 6, 1997
PubMed
Summary

Transgenic livestock offer dual benefits: producing pharmaceuticals via gene "pharming" and enhancing milk composition for food. Overcoming technological hurdles is key to realizing their full potential in agriculture and medicine.

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Area of Science:

  • Biotechnology
  • Animal Science
  • Genetics

Background:

  • Transgenic animal models are advancing fundamental knowledge.
  • Transgenic livestock are being developed for improved production and novel products.
  • Mammary-specific gene modification offers diverse research opportunities.

Purpose of the Study:

  • To explore the potential of gene "pharming" in transgenic livestock for pharmaceutical production.
  • To investigate the genetic engineering of bovine mammary glands for improved milk composition.
  • To assess the feasibility and profitability of using transgenic animals as bioreactors.

Main Methods:

  • Developing transgenic livestock by modifying mammary-specific genes.
  • Utilizing mammary glands as ideal sites for producing and purifying complex bioactive proteins.

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  • Conducting initial studies in transgenic mice to assess milk enhancement feasibility.

    • Main Results:

    • The gene "pharming" industry has created numerous companies and products in human clinical trials.
    • Research into altering milk composition for human consumption shows encouraging initial results.
    • The potential profitability of gene "pharming" and enhanced milk production is significant.

    Conclusions:

    • Transgenic cattle hold promise for both pharmaceutical production and optimized food products.
    • Current inefficiencies in transgenic technology, including low gene integration and embryo survival, limit widespread application.
    • Addressing these technological limitations is crucial for realizing the full potential of transgenic cattle.