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Updated: Oct 3, 2026

Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate
Published on: December 12, 2015
Metabolic acidosis
1Adult Critical Care Nurse Practitioner Program, University of Pennsylvania School of Medicine, Philadelphia, USA.
Abstract:
Metabolic acidosis is a pathophysiologic state that is associated with serious morbidities and mortality. The diagnosis of metabolic acidosis is perplexing for novice and expert advanced practice nurses for many reasons. Its differential diagnosis is broad and includes common and rare, complex disease. The diagnosis of metabolic acidosis is also difficult because it is frequently associated with mixed, acid-base disorders. Its clinical manifestations are often nonspecific or subclinical, which means that its diagnosis is made from laboratory and other diagnostic tests. Timely diagnosis of metabolic acidosis is needed to institute appropriate therapy to avoid negative physiologic effects.
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