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Antinociception induced by verapamil and chloramphenicol in mice
1Department of Pharmacology and Toxicology, Faculty of Medicine, Kocaeli University, Derince-Izmit, Turkey.
Biology of the Neonate
|January 1, 1997
Abstract:
The analgesic effects of verapamil, a calcium channel blocker, and chloramphenicol, a phenicolated antibiotic, were compared using the test of acetic-acid-induced writhing and the hot-plate test in mice. The results suggest that both drugs have antinociceptive properties comparable to salicylate analgesia. No significant difference was found between verapamil- and chloramphenicol-induced analgesia (p < 0.05).