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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Conceptual basis for advances in the systemic drug therapy of breast cancer

L Norton1

  • 1Breast Cancer Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Seminars in Oncology
|August 1, 1997
PubMed

Insights

Optimizing chemotherapy for breast cancer involves adjusting drug intensity and scheduling. Research focuses on maximizing patient responses and managing disease progression for better treatment outcomes.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Breast cancer treatment aims to improve patient outcomes.
  • Chemotherapy remains a cornerstone for managing neoplastic progression and symptoms.

Purpose of the Study:

  • To review current knowledge and ongoing research in systemic therapy for breast cancer.
  • To explore future directions in optimizing chemotherapy dosing and scheduling.

Main Methods:

  • Review of current literature and clinical trial protocols.
  • Analysis of strategies in drug dosing, scheduling, and intensity manipulation.

Main Results:

  • Progress in chemotherapy response is linked to optimized drug dosing and novel scheduling.
  • Altering drug intensity and employing new scheduling strategies improve treatment responses.

Conclusions:

  • Optimizing chemotherapy through dose and schedule manipulation is crucial for breast cancer treatment.
  • Emerging concepts like limits of cytoreduction are important for clinical trials.

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