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Related Experiment Videos

Immaturity, ageing and oral tolerance

N Vaz1, A M Faria, B A Verdolin

  • 1Department of Biochemistry and Immunology, ICB, UFMG, Belo Horizonte, Brazil.

Scandinavian Journal of Immunology
|October 7, 1997
PubMed
Summary

Oral tolerance, the immune system

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Area of Science:

  • Cellular immunology
  • Immunological tolerance
  • Oral tolerance induction

Background:

  • Early studies suggested immune tolerance is established only in embryonic or neonatal stages.
  • This implied immature hosts are necessary for self-tolerance development.
  • Contradictory evidence shows oral tolerance occurs in adult animals.

Purpose of the Study:

  • To review findings on oral tolerance.
  • To emphasize ongoing immunological activity throughout life.

Main Methods:

  • Review of existing literature on oral tolerance.
  • Analysis of studies on immune tolerance induction in adult versus young hosts.

Main Results:

  • Oral tolerance is a common phenomenon in adult immunocompetent animals.
  • Susceptibility to oral tolerance induction decreases after the neonatal period.
  • Tolerance induction can be restored by transferring cells from young hosts.

Conclusions:

  • Immunological activity is a continuous process throughout an organism's lifespan.
  • Immune system development and tolerance extend beyond early ontogenesis.

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