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Decreases in CD5+ B lymphocytes in children with the DiGeorge anomaly
A P Kourtis1, C C Ibegbu, F K Lee
1Division of Pediatric Infectious Diseases, Epidemiology and Immunology, Emory University, Atlanta, GA 30303, USA.
Scandinavian Journal of Immunology
|October 7, 1997
Abstract:
The authors evaluated the lymphocyte subsets in eight children with the DiGeorge anomaly, compared with 48 age-matched control infants. Of particular interest was the finding that the percentage and number of CD5+ B lymphocytes were decreased in seven of the eight cases. This observation may provide insight into thymic function and the interaction of the B and T cell systems in some forms of congenital and acquired immunodeficiencies.
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