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Life-threatening toxicity of oral tegafur-uracil (UFT) plus leucovorin
1Hospital General Universitari Vall d'Hebron, Barcelona, Spain.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|January 1, 1997
Abstract:
UFT. a a combination of tegafur and uracil, is increasingly used in the treatment of gastrointestinal malignancies. We report on a life-threatening toxicity observed in a 74-year-old female while undergoing adjuvant treatment with oral UFT plus leucovorm for adenocarcinoma of the rectum. The patient developed grade 4 thrombocytopenia, grade 4 neutropenia, grade 3 infection, grade 3 neurotoxicity and grade 2 cutaneous toxicity. This oral double-agent regimen should be used with caution in the adjuvant treatment of elderly patients with gastro-intestinal malignancies.