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Aging, neuroendocrine function, and osteoporosis

M Peterlik1

  • 1Department of General and Experimental Pathology, University of Vienna Medical School, Austria.

Experimental Gerontology
|July 1, 1997
PubMed
Summary
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Osteoporosis involves age-related bone loss due to impaired bone remodeling. This review explores how hormones and neurotransmitters influence bone turnover and age-related endocrine changes contributing to osteoporosis.

Area of Science:

  • Bone biology and endocrinology
  • Metabolic bone diseases

Background:

  • Osteoporosis is characterized by reduced mineralized bone matrix and age-related bone loss.
  • It results from uncoupled bone remodeling (resorption and formation).
  • Both women and men can develop osteoporosis.

Purpose of the Study:

  • To review the role of systemic hormones and local mediators in bone turnover.
  • To discuss the impact of age-related neuroendocrine dysfunction on bone remodeling and osteoporosis development.

Main Methods:

  • Literature review of systemic hormones, local mediators, neuropeptides, and neurotransmitters.
  • Analysis of age-related endocrine changes and their effect on bone remodeling.

Main Results:

Related Experiment Videos

  • Systemic hormones and local mediators, including neuropeptides and neurotransmitters, significantly control bone turnover.
  • Age-related neuroendocrine dysfunction is implicated in the development of osteoporosis.

    • Conclusions:

    • Understanding the interplay of hormonal and neural factors is crucial for osteoporosis management.
    • Age-related changes in the neuroendocrine system contribute to the pathogenesis of osteoporosis.