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Bupropion and sexual function: a placebo-controlled prospective study on diabetic men with erectile dysfunction
D L Rowland1, L Myers, A Culver
1Department of Psychology, Valparaiso University, IN 46383, USA. DROWLAND@exodus.valpo.edu
Journal of Clinical Psychopharmacology
|October 8, 1997
Summary
Bupropion, an antidepressant, did not negatively impact sexual function in men with diabetes and erectile dysfunction. This study suggests bupropion may even improve sexual response without affecting diabetic control.
Area of Science:
- Pharmacology
- Endocrinology
- Sexual Medicine
Background:
- Antidepressant medications frequently cause sexual dysfunction.
- Diabetic men with erectile dysfunction represent a population with high unmet needs for effective and safe treatments.
Purpose of the Study:
- To evaluate the sexual side effects, both positive and negative, of bupropion.
- To assess the impact of bupropion on erectile function and overall sexual performance in nondepressed diabetic men.
Main Methods:
- A single-blind, prospective study involving 14 nondepressed diabetic men with erectile dysfunction.
- A 10-week protocol including baseline, placebo, and bupropion treatment phases.
- Assessment of subjective and objective measures of sexual functioning, alongside physiological assessments and diabetic control monitoring.
Main Results:
- Bupropion did not worsen subjective or objective measures of erectile and overall sexual functioning.
- A trend towards improved sexual functioning was observed in several measures.
- Bupropion administration did not affect diabetic control.
Conclusions:
- Bupropion appears to be a safe option regarding sexual function in diabetic men with erectile dysfunction.
- The amino-ketone antidepressant bupropion may offer potential benefits for sexual response in this population.
- Bupropion could be a suitable treatment choice for depression in diabetic men concerned about sexual dysfunction.