Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Angiotensin's role in renal development

K F Hilgers¹, V F Norwood, R A Gomez

¹Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA.

Seminars in Nephrology

|October 8, 1997

Summary

Angiotensin is crucial for normal kidney development and function. Inhibiting the renin-angiotensin system (RAS) or its components causes kidney abnormalities, highlighting angiotensin's essential role.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hispanic American osteoarthritis patients' and partners' perspectives regarding exercise: A qualitative study.

Osteoarthritis and cartilage open·2025

Same author

Where Does Some of the Ingested Sodium Chloride Hide without Exerting Osmotic Pressure?: Internal Sodium Balance in DOCA-Salt Rats: A Body Composition Study. Am J Renal Physiol 289: F793-F802, 2005.

Journal of the American Society of Nephrology : JASN·2023

Same author

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension.

Nature communications·2020

Same author

In-situ analysis of mast cells and dendritic cells in coronary atherosclerosis in chronic kidney disease (CKD).

Histology and histopathology·2018

Same author

RBP-J in FOXD1+ renal stromal progenitors is crucial for the proper development and assembly of the kidney vasculature and glomerular mesangial cells.

American journal of physiology. Renal physiology·2013

Same author

Sympathetic blockade prevents the decrease in cardiac VEGF expression and capillary supply in experimental renal failure.

American journal of physiology. Renal physiology·2010

Area of Science:

Nephrology
Developmental Biology
Molecular Biology

Background:

The renin-angiotensin system (RAS) is expressed during kidney development.
RAS components play a role in nephrogenesis, vascularization, and kidney architecture.
Pharmacological RAS inhibition causes kidney developmental abnormalities.

Purpose of the Study:

To investigate the role of the renin-angiotensin system (RAS) in kidney development and maintenance.
To understand the impact of genetic inactivation of RAS components on renal morphology and function.

Main Methods:

Review of existing literature on RAS components in kidney development.
Analysis of studies involving pharmacological inhibition of RAS.
Examination of knockout mouse models for angiotensinogen (Agt) and angiotensin-converting enzyme (ACE) genes.

Main Results:

RAS components are spatially and temporally expressed during kidney development.
Pharmacological RAS inhibition and genetic inactivation of Agt or ACE lead to renal abnormalities.
Inactivation of angiotensin receptors did not result in renal morphological abnormalities, suggesting redundancy.
ACE or Angiotensinogen gene inactivation yields phenotypes similar to pharmacological RAS inhibition.

Conclusions:

Angiotensin is essential for normal kidney development.
The RAS plays a critical role in maintaining the structural and functional integrity of both developing and adult kidneys.
Redundancy in angiotensin receptors may prevent pathology upon their inactivation.

Related Experiment Videos