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Related Experiment Videos

The artificial heart. Progress and promise

W S Pierce, J A Brighton, J H Donachy

    Archives of Surgery (Chicago, Ill. : 1960)
    |December 1, 1977
    PubMed
    Summary

    Researchers developed an artificial heart with improved pump design, leading to increased survival times in calf studies. Further development depends on funding and investigator dedication for eventual clinical use.

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    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Research
    • Medical Device Development

    Background:

    • Artificial heart research aims to provide a viable alternative for patients with end-stage heart failure.
    • Previous artificial heart designs faced challenges in durability, biocompatibility, and physiological responsiveness.

    Purpose of the Study:

    • To design, fabricate, and evaluate a novel artificial heart system.
    • To assess the performance and long-term functionality of the artificial heart in an animal model.
    • To identify and overcome challenges in artificial heart development for potential clinical application.

    Main Methods:

    • A multidisciplinary team designed an artificial heart comprising two sac-type pumps, pneumatic power units, and an electronic control system.
    • The artificial heart system was implanted and evaluated in 22 calves over an extended period.

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  • System performance was assessed through monitoring survival times, animal well-being, and control system responsiveness.

    • Main Results:

    • Significant improvements in artificial heart pump design were achieved through iterative refinement.
    • Calves implanted with the device demonstrated progressively increasing survival times, with the longest reaching 60 days.
    • The electronic control system effectively balanced pump output and automatically adjusted cardiac output during exercise.

    Conclusions:

    • The developed artificial heart shows promise, with no insurmountable technical challenges identified.
    • The study confirmed the control system's capability for long-term function and exercise response.
    • Clinical availability of this artificial heart is contingent upon continued funding and research efforts.