Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The artificial heart. Progress and promise

W S Pierce, J A Brighton, J H Donachy

    Archives of Surgery (Chicago, Ill. : 1960)
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Variable Neighbourhood Descent Heuristic for Conformational Search Using a Quantum Annealer.

    Scientific reports·2019
    Same author

    HBeAg levels at week 24 predict response to 8 years of tenofovir in HBeAg-positive chronic hepatitis B patients.

    Alimentary pharmacology & therapeutics·2017
    Same author

    Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report.

    BMC neurology·2017
    Same author

    Why a journal of biomechanical engineering?

    Journal of biomechanical engineering·2013
    Same author

    [Is bovine leishmaniasis spreading in Switzerland?].

    Schweizer Archiv fur Tierheilkunde·2012
    Same author

    Can we slow the aging process?

    Canadian family physician Medecin de famille canadien·2011
    Same journal

    The White Test: A New Dye Test for Intraoperative Detection of Bile Leakage During Major Liver Resection-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Use of Vascular Clamping in Hepatic Surgery: Lessons Learned From 1260 Liver Resections-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Liver Resection With a New Multiprobe Bipolar Radiofrequency Device-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Porcine and Bovine Surgical Products: Jewish, Muslim, and Hindu Perspectives-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Neuroendocrine Liver Metastasis: Transplant as Part of Multimodality Liver-Directed Therapy-Reply.

    Archives of surgery (Chicago, Ill. : 1960)·2016
    See all related articles

    Researchers developed an artificial heart with improved pump design, leading to increased survival times in calf studies. Further development depends on funding and investigator dedication for eventual clinical use.

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Research
    • Medical Device Development

    Background:

    • Artificial heart research aims to provide a viable alternative for patients with end-stage heart failure.
    • Previous artificial heart designs faced challenges in durability, biocompatibility, and physiological responsiveness.

    Purpose of the Study:

    • To design, fabricate, and evaluate a novel artificial heart system.
    • To assess the performance and long-term functionality of the artificial heart in an animal model.
    • To identify and overcome challenges in artificial heart development for potential clinical application.

    Main Methods:

    • A multidisciplinary team designed an artificial heart comprising two sac-type pumps, pneumatic power units, and an electronic control system.
    • The artificial heart system was implanted and evaluated in 22 calves over an extended period.

    Related Experiment Videos

  • System performance was assessed through monitoring survival times, animal well-being, and control system responsiveness.

    • Main Results:

    • Significant improvements in artificial heart pump design were achieved through iterative refinement.
    • Calves implanted with the device demonstrated progressively increasing survival times, with the longest reaching 60 days.
    • The electronic control system effectively balanced pump output and automatically adjusted cardiac output during exercise.

    Conclusions:

    • The developed artificial heart shows promise, with no insurmountable technical challenges identified.
    • The study confirmed the control system's capability for long-term function and exercise response.
    • Clinical availability of this artificial heart is contingent upon continued funding and research efforts.