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Etiology of catheter-associated sepsis. Correlation with thrombogenicity

R M Stillman, F Soliman, L Garcia

    Archives of Surgery (Chicago, Ill. : 1960)
    |December 1, 1977
    PubMed

    Insights

    Central venous catheters with thrombus formation showed higher rates of bacterial contamination. Non-thrombogenic catheter materials were associated with reduced bacterial contamination, suggesting a link between thrombosis and infection risk.

    Area of Science:

    • Medical Devices
    • Infectious Diseases
    • Cardiovascular Medicine

    Background:

    • Central venous catheters (CVCs) are essential for patient care but are associated with infection risks.
    • Thrombus formation on CVCs is a known complication that may facilitate bacterial colonization.

    Purpose of the Study:

    • To investigate the relationship between thrombus deposition on CVCs and microbial colonization.
    • To assess the impact of catheter material on thrombus formation and bacterial contamination.

    Main Methods:

    • Observation of 94 removed central venous catheters for intraluminal and surface thrombus.
    • Correlation of gross thrombus evidence with microbiological culture results.
    • Comparison of contamination rates between different catheter materials.

    Main Results:

    • Catheters with positive cultures consistently showed thrombus formation.
    • Catheters with negative cultures were generally free of thrombus.
    • Devices made from ethylene acrylic acid exhibited less thrombus and bacterial contamination.

    Conclusions:

    • Thrombus deposition on central venous catheters is strongly associated with bacterial colonization.
    • Non-thrombogenic catheter materials may reduce the risk of both thrombus formation and subsequent infection.

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