Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin D and multiple sclerosis

C E Hayes1, M T Cantorna, H F DeLuca

  • 1Department of Biochemistry, University of Wisconsin-Madison 53706, USA.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|October 8, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The immunological functions of the vitamin D endocrine system.

Cellular and molecular biology (Noisy-le-Grand, France)·2003
Same author

Genetic studies of B-lymphocyte deficiency and mastocytosis in strain A/WySnJ mice.

Immunogenetics·2002
Same author

Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers.

Current biology : CB·2001
Same author

Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Radio-frequency coil selection for MR imaging of the brain and skull base.

Radiology·2001
Same author

Rag-1-dependent cells are necessary for 1,25-dihydroxyvitamin D(3) prevention of experimental autoimmune encephalomyelitis.

Journal of neuroimmunology·2001

Vitamin D3, specifically its active form 1,25-dihydroxyvitamin D3, may prevent multiple sclerosis (MS). Low sunlight reduces vitamin D3 production, increasing MS risk. This vitamin D connection explains MS geographic patterns.

Area of Science:

  • Neuroimmunology
  • Endocrinology
  • Environmental Health

Background:

  • Multiple Sclerosis (MS) is an autoimmune disease with both genetic and environmental factors.
  • Experimental autoimmune encephalomyelitis (EAE) is a mouse model for MS.
  • Exogenous 1,25-dihydroxyvitamin D3 (the active form of vitamin D3) prevents EAE in mice.

Purpose of the Study:

  • To investigate the hypothesis that sunlight exposure, influencing vitamin D3 production, is a key environmental factor in MS.
  • To explore the role of vitamin D3 as an immune regulator in preventing autoimmune diseases like MS.
  • To assess the potential therapeutic and preventative roles of 1,25-dihydroxyvitamin D3 and its analogs in MS.

Main Methods:

  • Review of existing evidence linking vitamin D3, sunlight exposure, and MS prevalence.

Related Experiment Videos

  • Analysis of geographic distribution patterns of MS in relation to latitude and altitude.
  • Examination of experimental data from EAE studies concerning vitamin D3's effects.

    • Main Results:

    • A strong correlation exists between lower sunlight exposure (higher latitudes) and increased MS rates.
    • Geographic anomalies in MS distribution (e.g., Switzerland, Norway) are explained by variations in UV intensity and dietary vitamin D3.
    • Experimental studies support vitamin D3's role in reducing susceptibility to EAE, the MS model.

    Conclusions:

    • Vitamin D3, influenced by sunlight, is a compelling protective environmental factor against MS.
    • Insufficient vitamin D3 production may increase MS risk, particularly in genetically susceptible individuals.
    • 1,25-dihydroxyvitamin D3 and its analogs show significant therapeutic and preventative potential for MS.