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Related Experiment Videos

Chronic exposure to morphine increases corticosteroid-binding globulin

B Nock1, M Wich, T J Cicero

  • 1Washington University School of Medicine, Department of Psychiatry, St. Louis, Missouri 63110, USA.

The Journal of Pharmacology and Experimental Therapeutics
|October 8, 1997
PubMed
Summary

Morphine significantly increases corticosteroid-binding globulin (CBG) in rats, reducing active corticosterone. This drug-induced change in CBG may impact drug use and corticosterone

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Area of Science:

  • Neuroendocrinology
  • Pharmacology

Background:

  • Corticosterone influences vulnerability to drugs of abuse.
  • Few studies investigate drug effects on factors modulating corticosterone efficacy.

Purpose of the Study:

  • To assess the effects of morphine on corticosteroid-binding globulin (CBG).
  • To understand how morphine alters corticosterone bioavailability.

Main Methods:

  • Adult male rats were administered morphine pellets.
  • Corticosteroid-binding globulin (CBG) levels were measured.
  • Naltrexone was used to block morphine effects.

Main Results:

  • Morphine caused a 160% naltrexone-preventable increase in CBG.
  • Elevated CBG levels persisted while morphine was detectable.

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  • Despite normal total corticosterone, free (active) hormone levels were reduced.

    • Conclusions:

    • Morphine significantly impacts corticosterone action by increasing CBG.
    • Elevated CBG may perpetuate drug use and impair normal corticosterone functions.