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Related Experiment Videos

Keratoconjunctivitis associated with sialodacryoadenitis in rats

Y L Lai, R O Jacoby, P N Bhatt

    Investigative Ophthalmology
    |July 1, 1976
    PubMed
    Summary

    A widespread Sialodacryoadenitis virus (SDA) infection in a rat colony caused severe keratoconjunctivitis and megaloglobus. Many rats developed chronic keratitis and ocular lesions, impacting vision and eye health.

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    Area of Science:

    • Veterinary Ophthalmology
    • Infectious Diseases
    • Rodent Models

    Background:

    • Keratoconjunctivitis presents significant challenges in laboratory animal colonies.
    • Ocular diseases can impact research validity and animal welfare.
    • Inbred Lewis/Wistar rats are common models in biomedical research.

    Purpose of the Study:

    • To investigate the cause and clinical presentation of keratoconjunctivitis in a specific rat colony.
    • To identify the etiological agent responsible for the observed ocular pathology.
    • To assess the long-term effects and associated conditions of the disease.

    Main Methods:

    • Clinical observation of affected rats from three weeks of age.
    • Ophthalmic examination to document lesions.
    • Sialodacryoadenitis virus (SDA) isolation from nasal washes.
    • Serological testing to confirm widespread viral infection.

    Main Results:

    • High incidence of keratoconjunctivitis with signs including discharge, opacity, and ulceration.
    • Six percent of rats developed megaloglobus, leading to lenticular and retinal degeneration.
    • Harderian dacryoadenitis was common; SDA virus was detected in nasal washes, not eyes.
    • Serological data confirmed widespread SDA virus infection within the colony.

    Conclusions:

    • Sialodacryoadenitis virus (SDA) is the likely cause of keratoconjunctivitis in this rat colony.
    • The infection led to acute and chronic ocular lesions, including megaloglobus and vision impairment.
    • Effective colony management and biosecurity are crucial to prevent viral spread and protect animal health.

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