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Critical thermal maximum in mice

G L Wright

    Journal of Applied Physiology
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Male mice acclimated to warmer temperatures showed a higher critical thermal maximum. Short-term heat exposure improved thermoregulation, but did not alter the upper thermal limit.

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    Area of Science:

    • Physiology
    • Environmental Science
    • Animal Biology

    Background:

    • Thermoregulation is crucial for animal survival, especially in fluctuating environments.
    • Understanding thermal limits helps predict species' responses to climate change.
    • Heat stress impacts physiological functions and can be lethal.

    Purpose of the Study:

    • To investigate the thermoregulatory responses and critical thermal maximum (CTM) in male mice.
    • To assess the effects of acute heat exposure and chronic heat acclimation on thermal tolerance.
    • To determine if short-term severe heat stress or prolonged moderate heat acclimation influences CTM.

    Main Methods:

    • Mice were exposed to high colonic temperatures (42°C and 44°C) and acclimated to different ambient temperatures (15°C and 30°C) for 14 days.

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  • The critical thermal maximum (CTM) was determined by measuring the colonic temperature at which heat-induced convulsions and righting reflex loss occurred.
  • Thermoregulatory responses were assessed by measuring heating time to breakdown at a high ambient temperature (40.8°C).

    • Main Results:

    • Mice acclimated to 30°C had a significantly higher CTM compared to those acclimated to 15°C.
    • Surviving exposure to 42°C or 44°C did not alter the CTM.
    • Heating time to thermoregulatory breakdown was extended by 100% in the 48 hours following exposure to 42°C.

    Conclusions:

    • Prolonged exposure to moderate heat (30°C acclimation) enhances the upper thermal limit in mice.
    • Severe, short-term heat stress (42°C exposure) improves thermoregulatory cooling capacity without changing the CTM.
    • Mice demonstrate adaptive thermoregulation, with different responses to acute versus chronic heat exposure.