Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Patterning neuronal connections by chemorepulsion: the semaphorins

M D Mark1, M Lohrum, A W Püschel

  • 1Molekulare Neurogenetik, Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstrasse 46, D-60528 Frankfurt/Main, Germany.

Cell and Tissue Research
|October 10, 1997
PubMed
Summary

Semaphorins are key signaling molecules guiding axonal growth cones during neural development. This review explores their conserved roles in patterning neuronal connections across species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of Raf kinase by phorbol ester does not correlate with enhanced phosphorylation or transactivation activity of tumor suppressor protein p53.

International journal of oncology·2011
Same author

Differential responsiveness to the chemorepellent Semaphorin 3A distinguishes Ipsi- and contralaterally projecting axons in the chick midbrain.

Developmental biology·2001
Same author

Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Axonal surface molecules act in combination with semaphorin 3a during the establishment of corticothalamic projections.

Cerebral cortex (New York, N.Y. : 1991)·2001
Same author

The semaphorin 3A receptor may directly regulate the activity of small GTPases.

FEBS letters·2000
Same author

Patterning of olfactory sensory connections is mediated by extracellular matrix proteins in the nerve layer of the olfactory bulb.

Journal of neurobiology·2000

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Axonal growth cones navigate complex pathways to form neuronal connections.
  • Numerous guidance cues influence these critical steering decisions.
  • Semaphorins represent a significant and expanding family of guidance molecules.

Purpose of the Study:

  • To review the role of semaphorins in neuronal development.
  • To highlight the conserved signaling mechanisms of semaphorins.
  • To discuss their involvement in patterning neuronal connections.

Main Methods:

  • Literature review of studies on semaphorin signaling.
  • Analysis of semaphorin expression patterns in various tissues.
  • Examination of conserved signaling pathways.

Related Experiment Videos

Main Results:

  • Semaphorins are a diverse family of secreted and membrane-bound proteins.
  • They are expressed in both neuronal and non-neuronal tissues.
  • Their conserved signaling systems are crucial for neuronal wiring.

Conclusions:

  • Semaphorins play a vital role in establishing precise neuronal connections.
  • Understanding semaphorin signaling enhances knowledge of neural development.
  • Further research continues to reveal the complexity of semaphorin functions.